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17 β -Hydroxymethyl-Steroide: Darstellung von Derivaten des 17 α Hydroxy17 β -hydroxymethyl-4-androsten-3-ons

AddTime:2019-07-25

react-text: 119 In situ bromination of 16α-methylpregnane-20-magnesium enolates gives a mixture of the 17α-bromo- and 17β-bromo-20-keto derivatives. Utilizing this reaction, 17α-bromo-16α-methylprogesterone and 17β-bromo-16α-methyl-17-isoprogesterone were prepared from 16-dehydropregnenolone acetate. /react-text react-text: 120 /react-text
Starting from methyl 3-oxo-4-etienate, the authors prepared 17β-hydroxymethyl-4-androsten-3-one and 11β-hydroxy-17β-hydroxymethyl-4-androsten-3-one. Chlorination of 17β-acetoxymethyl-4-androsten-3-one yielded 4-chloro-17β-acetoxymethyl-4-androsten-3-one. 17β-Hydroxymethyl-1, 4-androstadien-3-one was obtained from 17β-hydroxymethyl-4-androsten-3-one, both by chemical and biological methods.
he Vilsmeier-Haack reaction of 3-acetoxyandost-5-en-17-one ( 1 ) with phosporous oxychloride and dimethylformamide gave 3-acetoxy-17-chloro-16-formylandrosta-5,16-diene ( 2 ). Reaction of 2 with hydrazine and phenylhydrazine provided substituted 5-androsteno[17,16- d ]pyrazoles 3 and 4 respectively. Similarly, condensation of 2 with urea and guanidine hydrochloride revealed the formation of the corresponding substituted pyrimidines 5 and 6 respectively. Email:sales@danaopharm.com;Tel:+86-719-5251167/18986895161.
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